What is happening here
The Eucharistic Prayer is the center of the Mass and indeed of all Catholic worship. It is in this prayer that bread and wine become, by the power of the Holy Spirit, the Body and Blood of Christ — the Real Presence that Catholic teaching has held with absolute firmness for two thousand years.
The Eucharistic Prayer follows a recognizable structure across all the approved forms (the Roman Canon and Eucharistic Prayers II, III, and IV are the most commonly used). It opens with the Preface — a prayer of thanksgiving (the word "Eucharist" itself means "thanksgiving") that varies with the day or season. The Preface concludes with the Sanctus — "Holy, Holy, Holy Lord God of hosts. Heaven and earth are full of your glory. Hosanna in the highest." This is the song of the angels in Isaiah's vision and in Revelation, joined to the assembly's "Hosanna" from Christ's entry into Jerusalem.
After the Sanctus, the priest invokes the Holy Spirit (the epiclesis) over the bread and wine: "Make holy, therefore, these gifts, we pray, by sending down your Spirit upon them like the dewfall, so that they may become for us the Body and Blood of our Lord Jesus Christ." Then come the words of institution — Christ's own words at the Last Supper: "Take this, all of you, and eat of it, for this is my Body, which will be given up for you... Take this, all of you, and drink from it, for this is the chalice of my Blood..."
The mystery of faith is then proclaimed by the assembly. The Eucharistic Prayer continues with the anamnesis (the remembrance of Christ's death and resurrection), intercessions for the Pope and bishops, for the living and the dead, for the saints. It concludes with the Doxology and the Great Amen — "Through him, and with him, and in him, O God, almighty Father, in the unity of the Holy Spirit, all glory and honor is yours, for ever and ever." The assembly's "Amen" at this moment is the most important "Amen" of the Mass — the seal of consent on everything that the Eucharistic Prayer has accomplished.